Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties.
نویسندگان
چکیده
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 49 11 شماره
صفحات -
تاریخ انتشار 2001